Control of Cytoskeletal Dynamics in Cancer through a Combination of Cytoskeletal Components

The dynamic alterations in the cytoskeletal components actin and intermediate, etc. filaments are required for cell invasion migration. cytoskeleton is a highly structure that governed by delicate balance of filament formation disassembly. To controlling activities key epithelial mesenchymal transition (EMT) could be viable solution to metastasis. Bioinformatics technologies also allow researchers investigate consequences synthetic mutations or naturally occurring variations these proteins. S100A4 S100 protein family member interact with variety biological target. In study has shown interacts tumor suppressor p53, indicating may have additional roles development. p53 interaction increases after inhibition MDM2-dependent degradation using Nutlin-3A. main goal this research was control dynamics cancer through combination of, protein. molecular mechanism behind function promoting degradation. Understanding signaling pathways involved would provide better understanding changes occur during metastasis, which will eventually lead identification proteins can targeted treatment, resulting lower mortality.